What Receptors & Enzymes Does CBD Interact With?

For those of you interested in the finer biochemical interactions of cannabis — you’re not alone.

Here’s a list of the receptors and enzymes CBD has been shown to interact with:

  • 15‐lipoxygenase
  • 5HT1A receptor agonist (serotonin receptor)
  • 5‐lipoxygenase
  • Adenosine (A2a)
  • Arylalkylamine N‐acetyltransferase
  • FAAH
  • Glutathione peroxidase
  • Glutathione reductase
  • Indoleamine‐2,3‐dioxygenase
  • Mg2+‐ATPase
  • Phospholipase A2
  • PPARγ nuclear receptor
  • Vanilloid pain receptors (TRPV1, TRPV2, TRPV3)

Interestingly, CBD affects the psychedelic receptors — which are the same receptors used by magic mushrooms or LSD for causing their hallucinogenic effects. CBD interacts with this receptor differently — which is why it lacks the same psychedelic qualities.