Does CBD Interact With Other Medications?

CBD is generally regarded as safe and has a low potential for interacting with other drugs or supplements.

However, there are some exceptions to this rule.

The main issue CBD may pose with other medications involves the liver. The liver is responsible for metabolizing all kinds of compounds from the body, including naturally made ones like hormones or blood cells.

When we take large amounts of CBD that overwhelm the liver, it can cause other compounds that follow the same path of metabolism to become backed up. This can cause the effects of these drugs to last longer than expected — increasing the chances of producing side effects.

Each drug is metabolized by different enzymes in the liver. If you’re planning to use CBD in combination with other medications, we recommend asking your doctor if there are any known drug interactions with CBD. You can also look up the enzymes involved with metabolizing these drugs and compare them to the known enzymes involved with CBD metabolism.

CBD is metabolized by the specific liver enzymes:

• CYP1A1
• CYP1A2
• CYP1B1
• CYP2B6
• CYP2D6
• CYP3A5

Other drugs may interact with CBD if they work off any of the same pathways. This can include adenosine inhibitors, endocannabinoid agonists or antagonists, or opioid medications.

Always consult your doctor before taking CBD alongside other medications.